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Homologous Recombination in DSB repair

Homologous recombination (HR) comprises a series of interrelated pathways that function in the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In addition, recombination provides critical support for DNA replication in the recovery of stalled or broken replication forks, contributing to tolerance of DNA damage.

– by Li X, Heyer WD, “Homologous recombination in DNA repair and DNA damage tolerance, Cell Res. 2008 Jan;18(1):99-113. doi: 10.1038/cr.2008.1.